ReviewFrontiers in chemistry2026
Flexible molecular chameleons: structural adaptability and therapeutic applications.
Review in Frontiers in chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
There has been a growing focus on 'molecular chameleons' possessing structural flexibility; compounds that can dynamically adjust their conformations depending on the characteristics of the medium to either conceal or reveal polar parts in aqueous/lipidic environments. Drug discovery has shifted in the past few decades toward more complex molecules, such as cyclic and macrocyclic peptides, as well as PROteolysis-TArgeting Chimeras (PROTACs). These large macromolecules are intended to balance cell permeability, aqueous solubility, and strong target binding capacity for effective pharmacokinetics; though they are more difficult to design than conventional small drug molecules. Molecular chameleons are useful for this task because of their capacity to adapt to various environments. The science underlying the structural flexibility of molecular chameleons, their growing significance, role in therapeutics and design strategies using contemporary tools are all covered in this review.
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