Evidence map›Paper›PMID 42683077›Full record

ArticleMedicine international

Salinomycin is effective for clinically relevant radioresistant oral squamous cell carcinoma cancer cells and their cancer stem cell marker positive fraction.

Ryo Saga, Yoichiro Hosokawa, Manabu Fukumoto

Abstract read
In one paragraph

Article in Medicine international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ryo SagaDepartment of Radiation Science, Hirosaki University Graduate School of Health Sciences, Hirosaki, Aomori 036-8564, Japan.
Yoichiro HosokawaDepartment of Rehabilitation Science, Hirosaki University of Health and Welfare, Hirosaki, Aomori 036-8102, Japan.
Manabu FukumotoRadiological Disasters and Medical Science Laboratory, Disaster Medical Science Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi 980-8572, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Numerous patients with cancer experience metastasis, recurrence and resistance to chemotherapy and radiotherapy due to the presence of cancer stem cells (CSCs). Salinomycin (Sal) is a candidate for CSC-targeting therapy and may consequently sensitize tumors to radiation. Therefore, the present study investigated whether Sal can alleviate radioresistance using a clinically relevant radioresistant cell line and sorted CSC-like cells. The human oral squamous carcinoma cell line, SAS, and its radioresistant counterpart, SAS-R, were used. The fraction of CD24

Indexed as

cancer stem cellcell sorteroral squamous cell carcinomaradioresistancesalinomycin

Identifiers

PMID42683077
PMCPMC13531107

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.