ArticleIranian journal of basic medical sciences2026
Synergistic myelin regenerative, immunomodulatory and anti-inflammatory effects of vanillin and adipose derived stem cells in cuprizone animal model of multiple sclerosis.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Vanillin as a potential therapeutic agent along with transplantation of neurotrophic factors secreting cells, is considered a promising treatment for neurological disorders. In this study, the effects of vanillin in combination with human adipose derived stem cells transplantation were evaluated on oligodendrocyte differentiation, re-myelination, and motor function improvement. Materials and Methods: Female C57BL/6 mice were fed cuprizone (400 mg/kg/day) for 5 weeks to induce MS. Demyelinated mice were divided into MS, MS/vanillin, MS/stem cells, and MS/vanillin/stem cells groups. Additionally, sixteen mice were divided into control and sham groups for comparison. Motor function was assessed using the hanging wire test. Finally, serum levels of inflammatory (IL-2, IFN-γ) and anti-inflammatory (IL-10, TGF-β) factors, along with IgG, were measured by ELISA. The mean percentage of Olig2 and MOG-positive cells we determined using the immunohistochemical technique, and Luxal Fast Blue staining was performed to assess myelin density of corpus callosum. Results: The results revealed that the mean percentage of Olig2, Mog positive cells, the serum level of the IL-10 and TGF-β, myelin density, and behavior test score were significantly higher in treated groups specially in MS/vanillin/stem cells group ( Conclusion: Administration of vanillin with stem cell transplantation could be a suitable approach to accelerate the process of myelin repair in the nervous tissue.
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