Evidence map›Paper›PMID 42683025›Full record

ArticleClinical case reports2026

Clinical Benefit of Pembrolizumab in Lynch Syndrome-Associated Advanced Ovarian Cancer With Germline

Tomomi Yokozawa, Sayako Nakagawa, Yukio Suzuki, Aya Tokinaga-Uchiyama, Katsuyuki Konnai, Hiroto Narimatsu, Yukihiko Hiroshima, Haruya Saji

Abstract read
In one paragraph

Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomomi YokozawaDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0009-0001-6027-7840
Sayako NakagawaDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0009-0002-2400-9061
Yukio SuzukiDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0000-0002-2178-6562
Aya Tokinaga-UchiyamaDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0000-0002-7134-7437
Katsuyuki KonnaiDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0000-0002-2606-2950
Hiroto NarimatsuDepartment of Genetic Medicine Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0000-0002-0383-4911
Yukihiko HiroshimaDepartment of Cancer Genome Medicine Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0009-0005-7384-3513
Haruya SajiDepartment of Gynecology Kanagawa Cancer Center Yokohama Japan.ORCID https://orcid.org/0000-0003-2770-1731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first-line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.

Indexed as

comprehensive genomic profilinglynch syndromeMSH6ovarian cancerpembrolizumab

Identifiers

PMID42683025
PMCPMC13530852

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.