Evidence map›Paper›PMID 42682964›Full record

ArticleASM case reports2026

First UK use of bacteriophage therapy with DAIR for chronic

A Scobie, T Ferry, D Roulston, S Subbarao, T Thai, G Trafford, A Cudmore, J Miles, K Crick, S H Chin and 8 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in ASM case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

A ScobieESCMID Study Group for Non-Traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland.ORCID https://orcid.org/0000-0002-0941-9866
T FerryESCMID Study Group for Non-Traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland.
D RoulstonDivision of Medicine, University College London, London, United Kingdom.
S SubbaraoDepartment of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
T ThaiRoyal National Orthopaedic Hospital NHS Trust, London, United Kingdom.
G TraffordRoyal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.
A CudmoreRoyal Devon University Healthcare NHS Foundation Trust, Exeter, United Kingdom.
J MilesRoyal National Orthopaedic Hospital NHS Trust, London, United Kingdom.
K CrickRoyal National Orthopaedic Hospital NHS Trust, London, United Kingdom.
S H ChinRoyal National Orthopaedic Hospital NHS Trust, London, United Kingdom.
R LesterDepartment of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
S WarrenDepartment of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
N KarunaharanDepartment of Infection, Royal Free London NHS Foundation Trust, London, United Kingdom.
P-J CeyssensBacterial Diseases Unit, Sciensano, Brussels, Belgium.ORCID https://orcid.org/0000-0001-7735-8316
M MerabishviliLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium.
S DjebaraLaboratory for Molecular and Cellular Technology, Queen Astrid Military Hospital, Brussels, Belgium.
J-P PirnayESCMID Study Group for Non-Traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland.
T AzamgarhiESCMID Study Group for Non-Traditional Antibacterial Therapy (ESGNTA), Basel, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic Case Summary: We report the first UK case of intra-articular bacteriophage therapy administered alongside debridement, antibiotics, and implant retention (DAIR) for chronic methicillin-sensitive Conclusion: This case demonstrates the feasibility and safety of intra-articular phage therapy during DAIR in a UK setting but highlights biological, logistical, and pharmacological factors that may limit efficacy in advanced chronic PJI.

Indexed as

antimicrobial resistancebacteriophage or phage therapyprosthetic joint infectionsalvage therapyStaphylococcus aureus

Identifiers

PMID42682964
PMCPMC13532304

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.