Evidence map›Paper›PMID 42682955›Full record

ReviewFrontiers in pharmacology2026

Experimental models to study oxidative stress in glaucoma: integrating

Laxmi Moksha, Yan Zhu, Rebecca Salowe, Vrathasha Vrathasha, Rohini M Nair, Jie He, Mina Halimitabrizi, Gabriella Rice, Peter M J Quinn, Yuyan Cheng and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Laxmi MokshaCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Yan ZhuCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Rebecca SaloweCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Vrathasha VrathashaCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Rohini M NairF.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.
Jie HeCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Mina HalimitabriziCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.
Gabriella RiceF.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.
Peter M J QuinnF.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.
Yuyan ChengF.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.
Ahmara G RossF.M. Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, PA, United States.
Bruce KsanderSchepens Eye Research Institute of Massachusetts Eye and Ear, Boston, MA, United States.
Joan M O'BrienCenter for Genetics of Complex Disease, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, PA, United States.

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI CLAIRE H MITCHELL · 1985 to 2026
$19.5M
Primary Open Angle African-American Glaucoma Genetics Study RenewalR01EY023557 · NEI · UNIVERSITY OF PENNSYLVANIA · PI O'BRIEN, JOAN M · 2014 to 2025
$18.1M
NEI NIH HHS P30 EY001583NEI NIH HHS R01 EY023557
6 · The paper itself

Abstract

Glaucoma is a complex optic neuropathy and the leading cause of permanent blindness worldwide. Elevated intraocular pressure (IOP) is the major modifiable risk factor for this disease. Growing evidence suggests that oxidative stress and reactive oxygen species (ROS) are key mediators of retinal ganglion cell (RGC) death and optic nerve (ON) damage. In this review, we summarize experimental models that are routinely used to study oxidative stress in glaucoma and discuss the translational value of each model system for biomarker discovery and treatment development. This narrative review focuses on studies that emphasize experimental and clinical models relevant to oxidative stress in glaucoma. Primary experimental and clinical studies that directly investigated pathways of oxidative stress in glaucoma models were included for contextual synthesis.

Indexed as

glaucomaneurodegenerationoxidative stressreactive oxygen speciesretinal ganglion cells

Identifiers

PMID42682955
PMCPMC13530892

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.