ReviewMedicine international
Exosome-based strategies for periodontal regeneration: Current insights and future prospects (Review).
Review in Medicine international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The tooth-supporting structures gradually deteriorate due to periodontal disease and standard regenerative therapies are currently being modified using adjunctive strategies to optimise the treatment outcomes. Nanosized extracellular vesicles called exosomes, which contain bioactive molecules, function as mediators of immunomodulation, regeneration, and tissue repair. Recent research indicates that exosomes may enhance periodontal regeneration through immunomodulation, osteogenesis and angiogenesis from various stem cells. It is suggested that exosomes promote fibroblast proliferation, reduce inflammation and accelerate bone/cementum regeneration. Scaffold-loaded exosomes provide sustained release. The purpose of the present review was to discuss the functions of exosomes and their potential to be used as therapeutic agents in periodontal regeneration. For this purpose, the terms 'Exosomes', 'Extracellular Vesicles' and 'Periodontal Regeneration' were searched in Google Scholar, Web of Science and PubMed databases to identify articles in the English language published up to June, 2025. Grey literature was searched through an internet-based free tool created by the Canadian Agency for Drugs and Technologies in Health. Two independent reviewers evaluated the titles and abstracts of the retrieved studies, followed by a detailed review of the full texts to extract information relevant to the research objective. While further clinical research is required to validate their regenerative potential, the evidence generally points to exosomes as promising therapeutic agents. Although the available data are encouraging, standardized procedures and clinical trials are required before they can be routinely used in clinical settings, to address challenges with delivery and isolation.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.