ReviewFrontiers in pharmacology2026
Research advances on the gut-kidney axis theory in sepsis-associated acute kidney injury.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis-associated acute kidney injury (SA-AKI) is a common, high-mortality complication in critically ill patients, necessitating breakthroughs in prevention and treatment strategies. The "gut-kidney axis" theory offers a novel perspective. This review delves into the vicious cycle triggered by intestinal barrier disruption and dysbiosis in SA-AKI: pathogenic translocation, immune cell infiltration, and imbalances in nephrotoxic metabolites collectively drive renal inflammatory storms. Building upon these mechanisms, we systematically evaluate novel therapeutic approaches centred on microecological modulation, targeted anti-inflammatory immunotherapy, traditional Chinese medicine interventions, and vagus nerve electrical stimulation. These strategies aim to pioneer new pathways for the precise prevention and treatment of SA-AKI.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.