ReviewERJ open research2026
Eosinophil biology in COPD: from scientific insight to clinical treatment action.
Review in ERJ open research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
COPD is a common lung disease that causes significant global morbidity. Strikingly, elevated blood and/or airway eosinophil levels are observed in up to 40% of COPD patients. These innate immune cells are clinically associated with increased exacerbation frequency and risk. Eosinophils are key in COPD symptom management and a drive to uncover their related immunopathology is critical to our understanding of disease progression. Recent biologic treatments targeting eosinophils have had success in reducing symptoms in eosinophilic COPD patients. However, the underlying pathways that lead to these improvements is incompletely understood. Given eosinophils are important in pathogen clearance, mucus viscosity, barrier integrity and tissue remodelling, any disease modifying treatments will have several proposed mechanisms. In this narrative review, we summarise the developmental, recruitment, activation and related pathology of eosinophils in the context of eosinophil-depleting treatments to elucidate treatment efficacy. Furthermore, we highlight potential future biological pathways for therapeutics aimed at specific eosinophil mechanisms.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.