Evidence map›Paper›PMID 42682820›Full record

ArticleFrontiers in public health2026

Associations between legacy and emerging per and polyfluoroalkyl substances (PFAS) bioaccumulation and clinicopathological characteristics in breast cancer.

Bei Sun, Zhanhua Gao, Xiyue Liu, Gexue Liu, Shoujun Wang, Jinpu Liu, Junyi Wang, Haiyang Zhang, Mingqing Zhang, Chong Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bei Sun *Institute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Zhanhua Gao *Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Xiyue Liu *Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Gexue Liu *Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Shoujun Wang *Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Jinpu LiuTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Junyi WangTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Haiyang ZhangTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Mingqing ZhangTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Chong ChenTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Feng HeInstitute of Medical Engineering and Translational Medicine, Tianjin University, Tianjin, China.
Dongzhi HuTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Jie HaoTianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inroduction: Per and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants with endocrine-disrupting and carcinogenic potential. However, their bioaccumulation profiles and clinical relevance in human breast cancer remain largely unexplored. Methods: In this preliminary study we quantified the absolute concentrations of 33 PFAS congeners (ng/g) in paired tumour and adjacent non-tumorous tissues from 11 breast cancer patients ( Results: The detection rates for six compounds (HFPOTA, PFOA, PFNA, PFUnDA, PFOS, and 6:2Cl-PFESA) were greater than 40%. In paired samples, several congeners showed higher concentrations in tumour than in adjacent non-tumorous tissue; using a two-sided exact Wilcoxon signed-rank test with Hodges-Lehmann effect sizes, tumour enrichment remained significant after Benjamini-Hochberg correction for HFPOTA ( Discussion: Collectively, PFAS bioaccumulation was associated with breast cancer clinicopathological characteristics. Because the target genes are predicted rather than experimentally validated and the cohort is small (

Indexed as

Breast NeoplasmsEnvironmental PollutantsFluorocarbonsAdultAgedChromatography, LiquidFemaleHumansMiddle AgedEnvironmental PollutantsFluorocarbonsbioaccumulationbreast cancerclinicopathological characteristicslipid metabolismPFAStumor biomarkers

Identifiers

PMID42682820
PMCPMC13529988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.