ArticleInternational journal of nanomedicine2026
Antibacterial and Anticancer Evaluation of Copper-Aluminum (CuAl) Layered Double Hydroxides (LDH) Synthesized Using Co-Precipitation Method.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The advancement of nanotechnology has significantly accelerated the development of antibacterial and anticancer therapeutics for biomedical applications. Among emerging nanomaterials, layered double hydroxides (LDHs) offer several advantages, including ease of synthesis and inherent therapeutic properties. In this study, the antibacterial and anticancer activities of copper-aluminum (CuAl) LDHs were assessed. Methods: CuAl LDHs were synthesized via the co-precipitation method and characterized. Antibacterial activity was evaluated through broth microdilution, colony-forming unit (CFU) counts, followed by biofilm inhibition assays. Cytotoxicity experiments were conducted in monolayer and 3D tumor spheroid cultures, followed by mechanistic studies including reactive oxygen species (ROS), mitochondrial superoxide, apoptosis/necrosis, and cell cycle assays. Results: The particle sizes were 619.2 and 604.3 nm, with polydispersity index (PDI) values of 0.16 and 0.13 at pH 6 and 7.4, respectively. Zeta potential values ranged from +37.81 to +38.53 mV across pH 3 to 10, indicating good colloidal stability. The CuAl LDHs were effective against Gram-positive bacteria Conclusion: CuAl LDHs exhibit antibacterial, antibiofilm, and anticancer activities, indicating their potential as multifunctional materials for CRC-related biomedical applications. Their cytotoxic effects in CRC cells are associated with increased ROS generation, mitochondrial superoxide production, and apoptosis induction. Further studies are needed to assess their biocompatibility and selectivity toward normal cells, improve tumor-targeting capability, evaluate the implications of their relatively large particle size, and confirm the molecular mechanisms underlying their biological effects.
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