Predictors of cardiac autonomic neuropathy in patients with diabetic peripheral neuropathy.

Ali A Abdel Reheem, Azza A Hassan, Nermine E Abd-Allatif, Mona M Tahoun, Heba S Kassab

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Article in Journal of diabetes and metabolic disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Ali A Abdel ReheemDiabetes and Metabolism Unit, Faculty of Medicine, Alexandria University, Champollion Street, El Messallah, Alexandria, 21131 Egypt.

Azza A HassanDiabetes and Metabolism Unit, Faculty of Medicine, Alexandria University, Champollion Street, El Messallah, Alexandria, 21131 Egypt.

Nermine E Abd-AllatifDepartment of Internal Medicine, Diabetes and Metabolism Unit, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Mona M TahounClinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.

Heba S KassabDiabetes and Metabolism Unit, Faculty of Medicine, Alexandria University, Champollion Street, El Messallah, Alexandria, 21131 Egypt.ORCID 0000-0002-5463-7926

Funding

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6 · The paper itself

Abstract

Aims: The study aimed at assessment of predictors of cardiac autonomic neuropathy (CAN) among patients with established diabetic peripheral neuropathy (DPN). Methods: This cross-sectional study included 80 patients with DPN. Detailed history taking, physical examination and laboratory investigations were done. CAN was diagnosed by cardiac autonomic reflex tests which consists of the Valsalva ratio, lying standing heart rate (30/15 ratio), R-R interval variation, postural hypotension and sustained handgrip. Results: The majority of patients (about 91%) had CAN. Of them, 20% had early, 61.3% had definite and 10% had severe CAN. Compared to patients without CAN, patients with CAN were older ( Conclusions: The prevalence of CAN is very high among patients with DPN (91%). Old age, long DD, high WC and LDL-c level were associated with CAN. DD could be considered as a predictor of advanced stages of CAN (definite and severe).

Indexed as

Cardiac autonomic neuropathyDiabetes mellitusDiabetic peripheral neuropathyVascular complications

Identifiers

PMID42682755

DOI10.1007/s40200-026-02042-y

PMCPMC13530095

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