ArticleSmart molecules : open access2026
Hydrogen-bond-mediated retention of a phenolic SNAP analogue in polyvinyl alcohol/PEG hydrogels for sustained nitric oxide release and antibacterial activity.
Article in Smart molecules : open access, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Nitric oxide (NO)-releasing materials have attracted considerable interest for their potential in diverse biomedical applications. However, a persistent challenge is the leaching of NO donors from these materials, which leads to significantly reduced NO release durations and undesirable burst release effects. Herein, we demonstrate a novel hydrogen-bonding strategy to address NO donor leaching and the burst release of NO. A nitrosothiol-based NO hydrogel was developed by incorporating a SNAP analog bearing a 4-hydroxyphenethyl sidechain into polyvinyl alcohol (PVA)/PEG hydrogels. The hydrogel containing the structurally modified SNAP analog exhibited an elongation of over 300% and sustained NO release under physiological conditions. Hydrogen-bonding interactions contributed to the enhanced retention of the SNAP analog within the hydrogel network, extending donor retention to 144 h compared with the hydrogel containing unmodified SNAP (10 h). These NO-releasing hydrogels exhibited potent antibacterial activity against both
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