ArticleJournal of tissue engineering
In vitro pre-vascularized model of the human skin based on collagen hydrogel reinforced by fibrin-coated nanofibrous membrane.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
10 authors.
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Abstract
Introducing pre-vascularization in functional full-thickness skin equivalents is critical to improve inosculation upon implantation. This study introduces a mechanically reinforced, bi-layered human skin model comprised of epidermis and pre-vascularized dermis. By combining a collagen type I hydrogel with an electrospun PCL/PLCL nanofibrous membrane coated with fibrin provisional matrix, we developed a composite scaffold that prevents the cell-induced hydrogel contraction and replicates the mechanical heterogeneity of native skin. The model utilizes a simultaneous tri-culture of human endothelial cells, adipose tissue-derived stromal cells, and keratinocytes. A custom 3D-printed, adjustable insert for cultivation at an air-liquid interface facilitates stratification of the dermal and epidermal layers. Our results demonstrate that adipose tissue-derived stromal cells effectively function as pericyte-like stabilizers, driving the formation of dermal capillary-like networks in 3D. This reinforced, pre-vascularized model provides a tool for improving tissue substitutes
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