ArticleFrontiers in pediatrics2026
Development of a nomogram to predict acute liver injury in children with
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To construct and validate a nomogram for predicting acute liver injury in children with Methods: This retrospective study included 964 hospitalized children with confirmed MPP from January 2021 to December 2024. Acute liver injury was defined as the study endpoint. Missing data were handled by multiple imputation ( Results: Among the 964 children, 131 developed acute liver injury, corresponding to an incidence of 13.6%. The cohort was divided into a training set of 676 children, including 92 with acute liver injury, and a validation set of 288 children, including 39 with acute liver injury. Baseline characteristics were comparable between the training and validation sets ( Conclusion: This nomogram, based on routinely available clinical and laboratory indicators, may help identify children with MPP at increased risk of acute liver injury and support early liver function monitoring. Further prospective multicenter validation is needed.
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