ReviewFrontiers in microbiology2026
Fluoroquinolone resistance without fluoroquinolone use; the genie is truly out of the bottle.
Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
2 authors.
Funding
Abstract
The global dissemination of multidrug-resistant (MDR) bacteria is not merely a clinical byproduct of antibiotic overuse, but an evolutionary transition driven by highly successful, human-adapted clonal lineages. While MDR phenotypes are frequently associated with resistance to various drug classes, FQR-mediated by specific mutations in the Quinolone Resistance-Determining Regions (QRDR) of the chromosomal GyrA and ParC genes-stands out as a primary driver of clonal success. Contrary to the traditional "fitness cost" paradigm of antibiotic resistance, recent evidence suggests long-term commensal colonization of healthy individuals by MDR bacteria even in environments devoid of recent antibiotic use. This review analyzes the literature supporting the role of certain QRDR mutations in the commensal carriage of
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.