ArticleFrontiers in public health2026
Sex-specific mediating role of serum uric acid in the association between dietary diversity and muscle strength in urban community-dwelling older adults.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Dietary diversity is recognized as a key strategy for healthy aging, but the underlying mechanisms linking it to muscle strength, particularly those involving systemic metabolism, remain unclear. This study aimed to examine the association between dietary diversity and muscle strength and explore the potential mediating role of metabolic indicators. Methods: This cross-sectional study included 1,613 older adults (≥60 years) from the Anhui Urban Aging Cohort. Dietary diversity was assessed using a validated food frequency questionnaire to derive the dietary diversity score (DDS). Metabolic indicators-including serum uric acid (UA), the triglyceride-glucose (TyG) index, total cholesterol (TC), mean arterial pressure (MAP), and metabolic score (MS)-were measured from fasting blood samples. Muscle strength was evaluated by absolute handgrip strength (HGS), BMI-adjusted relative HGS, and low handgrip strength (LGS) defined by the Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Multiple linear and logistic regression models were used to examine the associations, while restricted cubic splines characterized nonlinear relationships. Mediation analysis was performed to assess the potential mediating effect of metabolic indicators. Results: Higher DDS was significantly associated with increased absolute HGS ( Conclusion: In urban community-dwelling older adults, dietary diversity benefited muscle strength and was partly mediated by serum uric acid. Notably, this mediating pathway was observed in men, whereas the null findings in women may reflect a complex association pattern. These findings underscore the necessity of considering sex-specific metabolic mechanisms in nutritional strategies against sarcopenia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.