ArticleFrontiers in nutrition2026
Dietary transition proxies and ischemic heart disease burden: a country-year panel analysis with a systematic robustness assessment.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dietary trans fatty acids (TFA) are established risk factors for ischemic heart disease (IHD) at the individual level, but the robustness of country-level ecological associations across dietary transition proxies has rarely been examined systematically. We constructed a country-year ecological panel (8,536 country-years; 194 countries; 1980-2023) linking GBD 2021 total trans-fat exposure, GBD 2023 IHD/stroke outcomes, FAOSTAT dietary supply proxies, WHO policy indicators, and World Bank covariates. Two-way fixed-effects regressions with country-clustered standard errors were estimated at 0-, 3-, 5-, and 10-year lags and subjected to a systematic robustness program: alternative exposure constructions, population weighting, leave-one-country-out refitting, sample-composition exclusions, formal tests of income- and country-size interaction, and multiple-comparison adjustment. At the 5-year lag, higher estimated total trans-fat exposure was associated with higher IHD incidence (
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