Evidence map›Paper›PMID 42682354›Full record

ArticleInternational journal of surgery (London, England)2026

Effects of TBK1 genetic polymorphisms and their interactions with hepatitis B virus mutations on the risk of hepatocellular carcinoma in Han Chinese population: a case-control study.

Ge Zhang, Hui Yang, Mingyan Fu, Ying Qin, Wenqing Cai, Yunning Hu, Yuxi Zhang, Yubao Zhao, Haibo Chen, Lu Ding and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ge ZhangDepartment of Gastroenterology, Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong.
Hui YangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.
Mingyan FuDepartment of Gastroenterology, Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong.
Ying QinDepartment of Gastroenterology, Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong.
Wenqing CaiSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.
Yunning HuSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.
Yuxi ZhangSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.
Yubao ZhaoDepartment of Infectious Diseases, Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong.
Haibo ChenInterventional Radiology Department, Second Affiliated Hospital of Shandong First Medical University, Tai'an, Shandong.
Lu DingDepartment of Public Health, Jinan Central Hospital, Jinan, Shandong, People's Republic of China.
Zhenhong SunSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.
Yang DengSchool of Public Health, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong.ORCID https://orcid.org/0000-0003-0082-1493

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: TANK-binding kinase 1 (TBK1) plays a critical role in driving inflammation and carcinogenesis. We aimed to investigate whether Methods: Four Results: Variant genotypes of rs12313449, rs73122364, and rs7486100 were associated with an increased risk of HCC. In genotype C HBV-infected subjects, GA and AA genotypes at rs12313449, AT and TT genotypes at rs73122364, and TA and AA genotypes at rs7486100 were associated with a higher prevalence of HBV mutations including T1753A/C, A1762T/G1764A, G1896A, and preS deletion, which increase HCC risk. The interactions of variant genotypes of rs12313449, rs73122364, and rs7486100 with T1753A/C, A1762T/G1764A, and G1896A were significantly associated with an increased HCC risk. Conclusions:

Indexed as

genetic polymorphismhepatitis B virushepatocellular carcinomaprognosisTANK-binding kinase 1

Identifiers

PMID42682354
PMCPMC13336618

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.