Deciphering the association between uric acid and kidney stones: insights into the mediating roles of BMI and serum iron: a cross-sectional study based on NHANES 2007-2018.

Ken Li, Chu Ann Chai, Yi Quan Tan, Wei Zhu, Guohua Zeng

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Article in International journal of surgery (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Ken LiDepartment of Urology, Guangzhou Institute of Urology, Guangdong Provincial Key Laboratory of Urological Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0009-0001-8816-0572

Chu Ann ChaiUrology Unit, Department of Surgery, University Malaya Medical Centre, Kuala Lumpur, Malaysia.ORCID https://orcid.org/0000-0001-8915-3617

Yi Quan TanDepartment of Urology, National University Health System, Singapore, Singapore.ORCID https://orcid.org/0000-0001-5303-4237

Wei ZhuDepartment of Urology, Guangzhou Institute of Urology, Guangdong Provincial Key Laboratory of Urological Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.

Guohua ZengDepartment of Urology, Guangzhou Institute of Urology, Guangdong Provincial Key Laboratory of Urological Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, Guangdong, China.ORCID https://orcid.org/0000-0002-3790-6434

Funding

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6 · The paper itself

Abstract

Background: The relationship between serum uric acid (UA) levels and the prevalence and recurrence of kidney stone (KS) remains unclear. This study aims to investigate the association between UA levels and the risk of KS in a large sample of U.S. adults. Methods: We analyzed the relationship between UA levels and the prevalence of KS among 24 039 U.S. adults from the 2007-2018 National Health and Nutrition Examination Survey. Multivariable logistic regression models were employed to assess the impact of UA on KS prevalence, while restricted cubic splines were used to explore potential nonlinear associations. Mediation analysis was conducted to examine the potential influence of body mass index (BMI) and serum iron on this relationship. Subgroup analyses were also performed to account for demographic differences. Results: Higher serum UA levels were significantly associated with an increased prevalence of KS (OR = 1.001, 95% CI: 1.000-1.002, Conclusion: Elevated UA levels are statistically associated with an increased prevalence of KS in U.S. adults but are not linked to recurrence. Serum iron and BMI may partially mediate this relationship. These findings underscore the potential role of UA as a target for KS prevention and offer insights into the underlying biological mechanisms.

Indexed as

BMIkidney stonesNational Health and Nutrition Examination Survey (NHANES)serum ironserum uric acid

Identifiers

PMID42682337

DOI10.1097/JS9.0000000000005126

PMCPMC13336615

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.