Evidence map›Paper›PMID 42681871›Full record

ArticleHGG advances2026

Genetic dissection of cardiac iron regulation using transcriptome network analysis and systems genetics in BXD mice.

Akhilesh K Bajpai, Qingqing Gu, Rakesh Kumar, Xiangtang Li, Athena Starlard-Davenport, Wenjing Zhang, Enkhsaikhan Purevjav, Byron C Jones, Qingyin Zheng, Dong Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in HGG advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akhilesh K BajpaiDepartment of Otolaryngology Head and Neck Surgery, Institute of Otology and Neurobiology, Shandong Medical and Pharmaceutical University Hospital, Binzhou, Shandong 256603, China; Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Qingqing GuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA; Affiliated Hospital of Nantong University, Department of Cardiology, Nantong, Jiangsu 226000, China.
Rakesh KumarDepartment of Anatomy, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Xiangtang LiDepartment of Pathology and Laboratory Medicine, University of Tennessee Health Science Center, Le Bonheur Children's Hospital, Memphis, TN 38103, USA.
Athena Starlard-DavenportDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Wenjing ZhangDepartment of Pathology, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Enkhsaikhan PurevjavDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Byron C JonesDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
Qingyin ZhengDepartment of Otolaryngology Head and Neck Surgery, Institute of Otology and Neurobiology, Shandong Medical and Pharmaceutical University Hospital, Binzhou, Shandong 256603, China; Shandong Key Lab of Complex Medical Intelligence and Aging, School of Special Education and Rehabilitation, Shandong Medical and Pharmaceutical University, Yantai, Shandong 264003, China.
Dong WangDepartment of Cardiology, Shandong Medical and Pharmaceutical University Hospital, Binzhou, Shandong 256603, China. Electronic address: binyiwangdong@126.com.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: llu@uthsc.edu.

Funding

Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
NHLBI NIH HHS R01 HL151438
6 · The paper itself

Abstract

Cardiac iron homeostasis is essential for myocardial energy metabolism and contractile function, yet the genetic and molecular mechanisms governing iron levels within the heart remain poorly understood. We used a systems genetics approach to dissect the transcriptional regulation of cardiac iron homeostasis. Myocardial iron level varies substantially across BXD strains (40-112 μg/g) and is under heritable genetic control (H

Indexed as

BXD mouse populationcardiac iron homeostasiscardiomyopathyQTL mappingsystems geneticsWGCNA

Identifiers

PMID42681871
PMCPMC13594880

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.