Evidence map›Paper›PMID 42681769›Full record

ArticleOrganic letters2026

Convergent Synthesis of a Bifunctional GPI as a Universal Platform to Access Diverse GPI and GPI-Anchored Protein Probes.

Xin Yan, Rajendra Rohokale, Zhongwu Guo

Abstract read
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In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xin YanDepartment of Chemistry, University of Florida, Gainesville, Florida32611, United States.ORCID 0000-0003-1846-3241
Rajendra RohokaleDepartment of Chemistry, University of Florida, Gainesville, Florida32611, United States.ORCID 0000-0001-8083-0466
Zhongwu GuoDepartment of Chemistry, University of Florida, Gainesville, Florida32611, United States.ORCID 0000-0001-5302-6456

Funding

Synthetic and Biological Studies of GPI Conjugates and GPI Anchorage to Cell MembranesR35GM131686 · NIGMS · UNIVERSITY OF FLORIDA · PI Zhongwu Guo · 2019 to 2026
$2.5M
Acquisition of timsTOF Pro for Complex Lipidomic AnalysesS10OD030250 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2022 to 2022
$658k
Acquisition of a Q Exactive HF Hybrid Quadrupole-OrbitrapS10OD021758 · OD · UNIVERSITY OF FLORIDA · PI BASSO, KARI B · 2017 to 2017
$600k
NIGMS NIH HHS R35 GM131686NIH HHS R35 GM131686NIH HHS S10 OD021758NIH HHS S10 OD030250Steven and Rebecca Scott Endowment NA
6 · The paper itself

Abstract

A bifunctional glycosylphosphatidylinositol (GPI) anchor containing an azide and a biotin to facilitate additional functionalization via click chemistry and avidin conjugation, respectively, was synthesized by a convergent strategy using an orthogonal protection tactic. It is a general platform to rapidly access diverse GPI and GPI-anchored protein (GPI-AP) probes. Spin-labeled GPI and GPI-AP derived from this platform were used in a related study to show that GPI governs the membrane orientation of GPI-AP, validating GPI as a unique protein anchor.

Indexed as

GlycosylphosphatidylinositolsAvidinAzidesBiotinClick ChemistryMolecular StructureAvidinAzidesBiotinGlycosylphosphatidylinositols

Identifiers

PMID42681769
PMCPMC13540377

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.