ArticleBMC pediatrics2026
Association and exploratory clinical significance of peripheral blood mononuclear cell microRNA-155 with T-Cell subset imbalance in newly diagnosed paediatric immune thrombocytopenia.
Article in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo investigate the association of peripheral blood mononuclear cell micro RNA-155 miR-155 expression with T-cell subset imbalance and disease severity in newly diagnosed paediatric immune thrombocytopenia (ITP).
methodsEighty-seven children with newly diagnosed ITP (43 severe, 44 non-severe) and 40 healthy controls were enrolled. Peripheral blood mononuclear cell miR-155 expression was measured via quantitative reverse transcription polymerase chain reaction; Th1, Th2, Th17 and regulatory T (Treg) cell proportions were detected using whole-blood flow cytometry and expressed as percentages of gated CD3
resultsPeripheral blood mononuclear cell miR-155 expression was significantly higher in patients with ITP than in controls and higher in severe than in non-severe ITP (P < 0.05); Th1 and Th17 cells, as well as Th1/Th2 and Th17/Treg ratios, were increased, whereas Th2 and Treg cells were decreased in ITP (P < 0.05); miR-155 expression was positively associated with Th1, Th17, Th1/Th2 and Th17/Treg and negatively associated with Th2, Treg and platelet count (P < 0.05). The exploratory combined model of miR-155, Th1/Th2 and Th17/Treg yielded an area under the curve of 0.928 (95%CI: 0.865-0.973) for severe ITP, with 79.10% sensitivity and 95.50% specificity.
conclusionPeripheral blood mononuclear cell miR-155 expression is associated with T-cell subset imbalance and disease severity in newly diagnosed paediatric ITP. The combined immune-cellular indicator may support severe-risk stratification, but prospective validation and functional studies are required.
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