Evidence map›Paper›PMID 42681476›Full record

ArticleAnalytical sciences : the international journal of the Japan Society for Analytical Chemistry2026

HPLC enantioseparation on composite chiral stationary phases based on homosubstituted and heterosubstituted amylose derivatives.

Shi-Yao Chen, Yi-Han Lou, Shou-Wan Tang

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Article in Analytical sciences : the international journal of the Japan Society for Analytical Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Shi-Yao ChenDepartment of Chemical Engineering, School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 318000, People's Republic of China.
Yi-Han LouDepartment of Chemical Engineering, School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 318000, People's Republic of China.
Shou-Wan TangDepartment of Chemistry, School of Pharmaceutical and Chemical Engineering, Taizhou University, Taizhou, 318000, People's Republic of China. tangswtz@163.com.ORCID http://orcid.org/0000-0002-0228-8912

Funding

Zhejiang University Student Science and Technology Innovation Activity Plan S202510350061
6 · The paper itself

Abstract

Coated-type composite chiral stationary phases (CSPs) based on homosubstituted (same substituents introduced onto the glucose unit) and heterosubstituted (different substituents grafted onto the glucose unit) amylose derivatives were prepared and their enantioseparation capabilities in high-performance liquid chromatography were evaluated. Investigations demonstrated that the enantioseparation capabilities of the composite CSPs generally fell in between those of the two single-component CSPs. Notably, several chiral analytes that failed to achieve resolution on the single-component CSPs were successfully discriminated on the composite ones, thereby extending the application scope of an individual amylose derivative-based CSP. Some anomalous retention and selectivity behaviors were also observed on the composite CSPs, which may be due to some interactions between the two polymers during cocoating. Additionally, the impact of mobile phase composition on enantioseparation was examined. In the hexane/2-propanol (80/20, 90/10, and 95/5, v/v) mobile phase system, a lower 2-propanol content in the mobile phase always results in higher retention factor k

Indexed as

Amylose derivativeChiral separationChiral stationary phaseColumn liquid chromatography

Identifiers

PMID42681476

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.