Evidence map›Paper›PMID 42681443›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Expression and Characterization of Blood Group Binding Lectins.

Hsien-Ya Lin, Shang-Chuen Wu, Hau-Ming Jan, Anu Paul, Victoria Ortiz, Courtney A Winters, Carter J Stowell, Vivien C Lee, Connie M Arthur

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hsien-Ya LinJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Shang-Chuen WuDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Hau-Ming JanDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Anu PaulDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Victoria OrtizDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Courtney A WintersJoint Program in Transfusion Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Carter J StowellDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Vivien C LeeDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Connie M ArthurDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA. cmarthur@bwh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Carbohydrate-binding proteins, often called lectins, possess the unique ability to engage other macromolecules through recognition of carbohydrate structures. Among lectins, galectins have emerged as unique mammalian lectins that can possess high specificity for human carbohydrate-based blood group antigens. As such, galectins can differentiate red blood cells (RBCs) based on the blood group status of an individual. The ability of galectins to engage glycans can be studied by a wide variety of approaches. We describe herein the production of galectins and the characterization of galectin glycanbinding affinity using isothermal titration calorimetry (ITC).

Indexed as

Blood Group AntigensGalectinsAnimalsCalorimetryGene ExpressionHumansLectinsPolysaccharidesProtein BindingBlood Group AntigensGalectinsLectinsPolysaccharidesBinding affinityBlood group antigensGalectinGalectin purificationIsothermal titration calorimetry

Identifiers

PMID42681443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.