Evidence map›Paper›PMID 42681442›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Anemia and Transfusion in Preclinical Models of Neonatology.

Mary Vallecillo-Zuniga, Samata P Varadkar, Carter J Stowell, Wenhui Li, Luke L Westhoff, Sean R Stowell, Connie M Arthur

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mary Vallecillo-ZunigaDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Samata P VaradkarDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Carter J StowellDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Wenhui LiDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Luke L WesthoffDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Sean R StowellDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA.
Connie M ArthurDivision of Transfusion Medicine, Mass General Brigham, Harvard Medical School, Boston, MA, USA. cmarthur@bwh.harvard.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anemia is one of the most common complications observed in preterm infants. Red blood cell (RBC) transfusion is a standard therapy for treating neonatal anemia, but it is not without risk. Several studies suggest that while transfusion may reverse anemia, it can also cause inflammation and impaired barrier function in the developing intestine, potentially leading to necrotizing enterocolitis. However, the features of the developing immune system in a preterm infant, along with the characteristics of the transfused RBC unit that contribute to neonatal complications, have been difficult to define using correlative clinical studies alone. To overcome this limitation, a phlebotomy-induced anemia model has been developed that allows for determining critical factors related to the pathology of anemia and the impact of various treatment options. This protocol defines the model of phlebotomy-induced anemia in murine pups for studying anemia and transfusion-associated gut injury and inflammation.

Indexed as

AnemiaAnemia, NeonatalBlood TransfusionErythrocyte TransfusionNeonatologyAnimalsAnimals, NewbornDisease Models, AnimalEnterocolitis, NecrotizingFemaleFlow CytometryHumansMicePhlebotomyFlow cytometryImmunohistochemistryPhlebotomy-induced anemiaSysmexTissue collectionTissue processingTransfusion

Identifiers

PMID42681442

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.