Evidence map›Paper›PMID 42681441›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Examining Inflammatory Effects of Reticulocyte Erythrophagocytosis in Human Macrophage Cultures.

Rosario Hernández-Armengol, Kausik Paul, Che-Yu Chang, June Young Lee, Krystalyn E Hudson, David R Gibb

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rosario Hernández-ArmengolCedars-Sinai Medical Center, Los Angeles, CA, USA. rosario.hernandezarmengol@cshs.org.
Kausik PaulDepartments of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Che-Yu ChangDepartments of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
June Young LeeDepartments of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Krystalyn E HudsonLaboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York City, NY, USA.
David R GibbCedars-Sinai Medical Center, Los Angeles, CA, USA. david.gibb@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Red blood cell (RBC) interaction with phagocytes in the spleen and liver may trigger or attenuate inflammatory responses that could influence innate and adaptive immune responses to RBC antigens. Such interactions are particularly relevant in patients with sickle cell disease (SCD), who have elevated rates of auto- and alloimmunity against RBC antigens. Many phagocyte-expressed pattern recognition receptors (PRRs) are intracellular and recognize nucleic acids. Reticulocytes and recently described mature RBCs abnormally retaining mitochondria have nucleic acids and, upon erythrophagocytosis, can access PRRs and affect inflammatory cytokine production. Here, we describe co-culture experiments of human macrophages and RBC subsets from patients with or without SCD to enable examination of erythrophagocytosis-induced inflammatory cytokine responses.

Indexed as

ErythrocytesInflammationMacrophagesPhagocytosisReticulocytesAnemia, Sickle CellCells, CulturedCoculture TechniquesCytokinesHumansInnate Immunity RecognitionCytokinesErythrophagocytosisRBC opsonizationReticulocyteSickle cell disease (SCD)Type 1 interferons (IFNα/β)

Identifiers

PMID42681441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.