Evidence map›Paper›PMID 42681427›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Methodological Approaches to Study Transfusion-Related Acute Lung Injury (TRALI): From Complement Activation to In Vivo Mouse Model.

Farahnaz Rayatdoost, Rick Kapur

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Farahnaz RayatdoostSanquin Blood Supply Foundation, Department Research and Amsterdam UMC location University of Amsterdam, Landsteiner Laboratory, Amsterdam, The Netherlands.
Rick KapurSanquin Research, Department of Experimental Immunohematology, Amsterdam and Landsteiner Laboratory, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. R.Kapur@sanquin.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transfusion-related acute lung injury (TRALI) is a life-threatening condition, with an increased risk in critically ill patients, characterized by acute non-cardiogenic pulmonary edema occurring within 6 h of blood/blood product transfusion. This chapter provides an overview of comprehensive methodological approaches for studying TRALI, focusing on both in vivo antibody-mediated TRALI and in vitro techniques. Key methodologies covered include assays for measuring the degree of pulmonary edema, bronchoalveolar lavage fluid analysis, neutrophil activation tests, complement system assays, and lung histology and immunohistochemistry. Addressing the challenges of standardizing protocols and replicating human immune responses is crucial for advancing TRALI research and improving diagnostic and therapeutic strategies in transfusion medicine.

Indexed as

Acute Lung InjuryComplement ActivationTransfusion ReactionTransfusion-Related Acute Lung InjuryAnimalsBronchoalveolar Lavage FluidDisease Models, AnimalHumansImmunohistochemistryLungMiceNeutrophil ActivationNeutrophilsComplement activationIn vitro assaysIn vivo modelsNeutrophil activationTransfusion-related acute lung injury (TRALI)

Identifiers

PMID42681427

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.