ArticleMethods in molecular biology (Clifton, N.J.)2026
Mouse Models of Transfusion-Related Acute Lung Injury (TRALI).
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transfusion-related acute lung injury (TRALI) is a serious hazard of blood transfusions typically caused by recipient-reactive antibodies in blood products. To model TRALI, we have used MHC class I antibody injections to trigger acute lung injury in mice. Studies using this approach have provided mechanistic insights into TRALI risk factors and pathogenesis. Beyond TRALI, the ability to rapidly provoke acute lung injury with a non-infectious causal agent has also been useful for studying antibody effector mechanisms, inflammatory platelet responses, neutrophil extracellular trap formation, and acute respiratory distress syndrome (ARDS) pathophysiology. Here, we provide a brief overview of mouse TRALI models, a protocol for inducing experimental TRALI, and key considerations for successful experiments.
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