ArticleMethods in molecular biology (Clifton, N.J.)2026
Modeling the Application of Chimeric Antigen Receptor T Cell Therapy to Eliminate Alloantibodies in Mice.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chimeric antigen receptor (CAR) T cell therapy has begun to show clinical promise as a strategy for immune-modulation in non-malignant conditions. In a murine model, we have demonstrated the utility of CAR T cells targeting B cells and plasma cells for the elimination of alloantibodies that cause allograft rejection. We describe a method for producing murine CAR T cells, their functional assessment in vitro, as well as their application in an in vivo transplant model. Our methods include a CAR production phase that involves retrovirus production, T cell isolation, activation, transduction and passage, and assessment of CAR expression by flow cytometry. Then, we describe methods for studying CAR T function in vitro using a cytotoxicity assay and in vivo using an islet transplant model.
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