Evidence map›Paper›PMID 42681418›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Tracking and Testing Transfused Versus Endogenous Platelets with Biotin or Human Leukocyte Antigen.

S Lawrence Bailey, Martin Bochenek, Danny Youngs, Idoia Gimferrer, Moritz Stolla

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S Lawrence BaileyBloodworks Northwest, Research Institute, Seattle, WA, USA.
Martin BochenekBloodworks Northwest, Research Institute, Seattle, WA, USA.
Danny YoungsBloodworks Northwest, Immunogenetics and HLA Laboratory, Seattle, WA, USA.
Idoia GimferrerBloodworks Northwest, Immunogenetics and HLA Laboratory, Seattle, WA, USA.
Moritz StollaBloodworks Northwest, Research Institute, Seattle, WA, USA. mstolla@bloodworksnw.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet transfusions are a critical and life-saving intervention utilized in bleeding patients and those at risk of bleeding. The laboratory assessment of fresh or stored platelets, both before and after transfusion, is of interest in licensing and basic science research. Platelets can be given either allogeneic (i.e., from a genetically different donor) or autologous (i.e., donor and recipient are the same, or genetically identical). In this protocol, we demonstrate how to distinguish circulating endogenous platelets from transfused platelets using biotinylation (useful for autologous and allogeneic transfusions) and HLA antibodies (practical in allogeneic transfusion scenarios) to differentiate between circulating endogenous and transfused platelets. Our described methodology not only enables the tracking of platelets but also facilitates post-transfusion functional assessment and the evaluation of platelet function post-transfusion using flow cytometry.

Indexed as

BiotinBlood PlateletsHLA AntigensPlatelet TransfusionBiotinylationFlow CytometryHumansBiotinHLA AntigensBiotinHuman plateletsPlatelet functionPlatelet HLAPlatelet labelingPlatelet storagePlatelet transfusion

Identifiers

PMID42681418

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.