ArticleMethods in molecular biology (Clifton, N.J.)2026
Quantification of Human Platelet Clearance In Vitro and in Xenotransfused Animals.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
3 authors.
Funding
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Abstract
We have utilized macrophage-dependent and hepatocyte-dependent phagocytosis assays as well as in vivo xenotransfusion experiments to determine the survival and rate of clearance of stored platelets in several conditions that include cold storage and the use of a novel preservative solution. Our novel preservative solution targets RHOA, a key signaling GTPase that controls refrigeration-induced storage damage. Using these approaches, the outcome of fluorescently labeled human platelets can be analyzed for their potential to be cleared by integrin-dependent phagocytes, lectin-binding domain-dependent hepatocytes or in circulation of thrombocytopenic, innate- and adaptive immunity-deficient animals.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.