Platelet Transfusions in Murine Models of Neonatal Thrombocytopenia.

Jesselin J Romero Escobar, Natalie E Kane, Erin L Soule-Albridge, Martha C Sola-Visner, Patricia E Davenport

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Jesselin J Romero EscobarDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. jesselin.romeroescobar@childrens.harvard.edu.

Natalie E KaneDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Erin L Soule-AlbridgeDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Martha C Sola-VisnerDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Patricia E DavenportDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have created a neonatal murine model of platelet transfusion to study the biological effects of platelet transfusions given to neonates. This model replicates the "developmental mismatch" that occurs when human preterm neonates receive a transfusion of functionally different adult platelets. These methods utilize common in vivo techniques that have been tailored for the small size of P1-P10 pups. Using this model and blood draw/analysis methods, investigators can prepare a washed, resting platelet transfusion product and transfuse it into a clinically relevant neonatal mouse model to interrogate both the hemostatic and immune functions of platelets and platelet transfusions in this important clinical context.

Indexed as

Blood PlateletsPlatelet TransfusionThrombocytopeniaThrombocytopenia, Neonatal AlloimmuneAnimalsAnimals, NewbornDisease Models, AnimalFemaleHumansMiceFacial-vein punctureNeonatal mousePlatelet transfusionRetro-orbital bleedRetro-orbital transfusion

Identifiers

PMID42681416

DOI10.1016/j.jtha.2023.12.022

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.