A Detailed Protocol to Induce and Treat Passive Immune Thrombocytopenia in Mice.

Yaima Tundidor, Lazaro Gil Gonzalez, Kevin Doyoon Won, Alequis Pavon Oro, Yuexin Shan, Alan H Lazarus

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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yaima TundidorDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Lazaro Gil GonzalezDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Kevin Doyoon WonDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Alequis Pavon OroDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Yuexin ShanDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada.

Alan H LazarusDepartment of Laboratory Medicine, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. alan.lazarus@unityhealth.to.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by the destruction of platelets through autoantibody-mediated mechanisms in most patients. Mouse models of ITP can serve as valuable tools for emulating key facets of human ITP pathology and facilitating the exploration of both conventional and innovative therapeutic strategies. This chapter outlines a passive model for inducing ITP using anti-platelet antibodies, with thrombocytopenia assessed by peripheral blood platelet enumeration. Furthermore, we detail a method of how to mitigate the thrombocytopenia in this model through the administration of intravenous immunoglobulin (IVIg).

Indexed as

Immunization, PassiveImmunoglobulins, IntravenousPurpura, Thrombocytopenic, IdiopathicAnimalsAutoantibodiesBlood PlateletsDisease Models, AnimalHumansMicePlatelet CountRabbitsAutoantibodiesImmunoglobulins, IntravenousCD41CytopeniaGlycoprotein IIbIIIaMurine modelPlatelet destructionRabbit anti-platelet serum

Identifiers

PMID42681415

DOI10.1016/j.immuni.2005.05.010

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.