Evidence map›Paper›PMID 42681411›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Miniaturized In Vitro Transfusion Model.

Erin L Soule-Albridge, Jesselin J Romero Escobar, Natalie E Kane, Martha C Sola-Visner, Patricia E Davenport

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Erin L Soule-AlbridgeDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. erin.soule-albridge@childrens.harvard.edu.
Jesselin J Romero EscobarDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Natalie E KaneDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Martha C Sola-VisnerDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Patricia E DavenportDepartment of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have created a miniaturized in vitro model of transfusion using neonatal (cord blood) and adult blood to investigate the immune and hemostatic changes that occur when a neonate receives a transfusion of functionally different adult platelets. These techniques allow us to model neonatal thrombocytopenia using neonatal cells (from cord blood) and create platelet concentrates of either neonatal or adult origin to mechanistically interrogate how the developmental state of the transfused platelets influences the hemostatic and/or immune responses of neonates to transfusion. These methods utilize common in vitro techniques that have been tailored for the unique characteristics of cord blood. Using this model, investigators can simulate platelet transfusions into a thrombocytopenic patient and investigate the effects of platelet transfusions in a human system.

Indexed as

Blood PlateletsMiniaturizationPlatelet TransfusionFetal BloodHumansInfant, NewbornThrombocytopeniaThrombocytopenia, Neonatal AlloimmuneCord bloodMiniaturized transfusionNeonatalPlatelet transfusionThrombocytopenia

Identifiers

PMID42681411

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.