Evidence map›Paper›PMID 42681398›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Pronuclear Transfer and Maternal Spindle Transfer in the Mouse.

Ross Stocker, Jeffrey R Mann, John Carroll

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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ross StockerMonash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. ross.stocker@monash.edu.
Jeffrey R MannMonash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
John CarrollMonash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Maternal Spindle Transfer (MST) and Pronuclear Transfer (PNT) are micromanipulation techniques that allow the transfer of the nuclear material from one oocyte or zygote to the cytoplasm of another. The application of these techniques has provided novel insights into nuclear-cytoplasmic interactions necessary for development, as well as fundamental discoveries such as genomic imprinting. Now, after extensive pre-clinical research, PNT and MST are starting to be used clinically for Mitochondrial Donation (also known as mitochondrial replacement therapy) and for patients with a history of repeated IVF failure. Here, we describe the methods for PNT and MST currently used in the mouse model. The techniques are readily adaptable for application to other mammalian species, including humans.

Indexed as

Cell NucleusNuclear Transfer TechniquesSpindle ApparatusAnimalsFemaleHumansMiceMitochondrial Replacement TherapyOocytesZygoteMaternal spindle transferMitochondrial diseaseMouseOocytePronuclear transferSendai virusZygote

Identifiers

PMID42681398

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.