Evidence map›Paper›PMID 42681394›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Modeling Early Human Embryo Implantation Using Human Endometrial Organoids and Embryo Surrogate Co-cultures for microRNA Transfection.

Wei Zhou, Michaela Sacco, Evdokia Dimitriadis

Abstract read
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Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Wei ZhouDepartment of Obstetrics, Gynecology and Newborn Health, University of Melbourne, Parkville, VIC, 3010, Australia.
Michaela SaccoDepartment of Obstetrics, Gynecology and Newborn Health, University of Melbourne, Parkville, VIC, 3010, Australia.
Evdokia DimitriadisDepartment of Obstetrics, Gynecology and Newborn Health, University of Melbourne, Parkville, VIC, 3010, Australia. evdokia.dimitriadis@unimelb.edu.au.ORCID http://orcid.org/0000-0002-4324-4772

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In vitro models of human implantation offer a powerful approach to studying the molecular and cellular events critical for a successful pregnancy. In this chapter, we describe a method that combines human endometrial epithelial organoids with human embryo surrogate co-cultures to model the early stages of implantation. Endometrial epithelial organoids, derived from primary tissue, are co-cultured with human cytotrophoblast progenitor cells to simulate the uterine microenvironment during implantation. This model enables a focused study of embryo adhesion and key signaling pathways, offering insights into the molecular mechanisms underlying implantation and reproductive disorders such as infertility.

Indexed as

Embryo ImplantationEndometriumMicroRNAsOrganoidsTransfectionCoculture TechniquesFemaleHumansModels, BiologicalPregnancyMicroRNAsCellular interactionsEmbryo adhesionEndometrial organoidsHuman embryo implantationInfertilityIn vitro modelMolecular mechanisms

Identifiers

PMID42681394

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.