Preparation of a Dithiol-Reactive Probe for PET Imaging of Cell Death.

Ivan Ho Shon, Michael P Gotsbacher, Jennifer Guille, Divesh Kumar, Rachel Codd, Philip J Hogg

Abstract read

In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ivan Ho ShonDepartment of Nuclear Medicine and PET, Prince of Wales Hospital, Randwick, NSW, Australia. i.hoshon@unsw.edu.au.

Michael P GotsbacherSchool of Medical Sciences (Pharmacology), Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

Jennifer GuilleDepartment of Nuclear Medicine and PET, Prince of Wales Hospital, Randwick, NSW, Australia.

Divesh KumarDepartment of Nuclear Medicine and PET, Fiona Stanley Hospital, Murdoch, WA, Australia.

Rachel CoddSchool of Medical Sciences (Pharmacology), Sydney Medical School, The University of Sydney, Sydney, NSW, 2006, Australia.

Philip J HoggSchool of Life Sciences, University of Technology Sydney and Centenary Institute, University of Sydney, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conjugates of 4-(N-(S-glutathionylacetyl)amino)phenylarsonous acid (GSAO) with optical or radionuclide probes are able to image cell death in vivo. GSAO conjugates are retained in the cytosol of dying and dead cells via the formation of covalent bonds between the As(III) ion and the thiol groups of proximal cysteine residues. Here, we describe the method for preparing a NODAGA-GSAO conjugate (hereafter referred to as cell death indicator, CDI-DX001) and its radiolabeling with gallium-68 (

Indexed as

ArsenicalsGlutathionePositron-Emission TomographyRadiopharmaceuticalsAcetatesAnimalsCell DeathGallium RadioisotopesHeterocyclic Compounds, 1-RingHumansToluene1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononaneAcetatesArsenicalsdithiolGallium-68Gallium RadioisotopesGlutathioneHeterocyclic Compounds, 1-RingRadiopharmaceuticalsTolueneBifunctional chelatorGallium-68GSAOPositron emission tomography

Identifiers

PMID42681373

DOI10.1021/bc300103t

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.