ArticleMethods in molecular biology (Clifton, N.J.)2026
Probing the Mechano-Redox Control of Cell Movement Using Microfluidic Assays.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The mechano-redox phenomenon-where mechanical forces and redox reactions synergistically regulate protein function-has been demonstrated in several mammalian proteins. Integrins, which mediate cellular adhesion to ligands, are particularly sensitive to redox modulation via thiol-disulfide exchange catalyzed by enzymes such as thiol isomerases. These redox-driven modifications can alter integrin conformation and ligand-binding affinity, ultimately leading to dynamic regulation of cell adhesion and de-adhesion. In this work, we present a suite of functional assays designed to investigate how manipulation of thiol exchange reactions influences key cellular processes, including thrombosis and inflammation. These assays employ either thiol-reactive enzymes or small-molecule inhibitors to modulate redox states. They include: (1) a cellular de-adhesion assay to monitor integrin-ligand interactions, (2) a neutrophil crawling assay to assess integrin-mediated motility, (3) a microfluidic thrombus formation assay to evaluate the contribution of thiol isomerases to clot development, (4) the "endo-chip"-a microfluidic platform integrating an endothelium for modelling vascular thromboinflammatory responses under flow, and (5) the microvascular-on-a-post chip, an endothelialized microfluidic device with fibrin-rich thrombosis localized on a 3D post.
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