Evidence map›Paper›PMID 42681322›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

MiREDiBase: A Comprehensive Resource for miRNA Editing Events.

Ilaria Cosentini, Gioacchino P Marceca, Rosario Distefano, Shaopeng Gu, Shaohong Feng, Eswar Shankar, Mario Acunzo, Giulia Romano, Alessandro Laganà, Ernesto Picardi and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ilaria CosentiniInstitute for Biomedical Research and Innovation (IRIB), National Research Council of Italy, Palermo, Italy.
Gioacchino P MarcecaIndependent Researcher, Vittoria, RG, Italy.
Rosario DistefanoDivision of Hematology, Department of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Shaopeng GuDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Shaohong FengDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Eswar ShankarDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, The Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Mario AcunzoDepartment of Medicine and Surgery, LUM "Giuseppe Degennaro" , Casamassima, Bari, Italy.
Giulia RomanoDivision of Pulmonary Diseases and Critical Care Medicine, Virginia Commonwealth University, Richmond, RG, USA.
Alessandro LaganàThe Tisch Cancer Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ernesto PicardiDepartment of Bioscience, Biotechnology and Environment, University of Bari, Bari, Italy.
Christian RolfoDivision of Medical Oncology, Department of Internal Medicine, College of Medicine, The Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA.
Qin MaDepartment of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
Giovanni NigitaPelotonia Institute for Immuno-Oncology, The Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Giovanni.nigita@osumc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA (miRNA) editing introduces a new layer of complexity in post-transcriptional gene regulation, with potential implications for miRNA biogenesis, target specificity, and function. However, the lack of a dedicated repository to comprehensively catalog miRNA editing events has hindered advances in the field. MiREDiBase addresses this gap by offering a meticulously curated database focused exclusively on validated, high-confidence putative miRNA editing events, with emphasis on A-to-I (adenosine-to-inosine) and C-to-U (cytidine-to-uridine) editing. This resource provides extensive annotations, including genomic locations, structural changes, and biological context, alongside tools for comparative analysis and predictive modeling of miRNA editing effects. MiREDiBase integrates data from experimental validation and high-throughput sequencing, delivering insights into the functional and pathological significance of miRNA editing across species. Unique features include a user-friendly interface for searching and comparing editing patterns, access to RESTful APIs for advanced data retrieval, and integration with external databases to enhance usability in epitranscriptomics research. By bridging the gap between RNA editing and miRNA research, MiREDiBase fosters innovative exploration of miRNA biology, advancing our understanding of its role in health and disease.

Indexed as

Computational BiologyDatabases, GeneticMicroRNAsRNA EditingAnimalsBiocurationEpitranscriptomicsHigh-Throughput Nucleotide SequencingHumansSoftwareMicroRNAsA-to-I RNA editingC-to-U RNA editingdatabaseEpitranscriptomicsmicroRNA

Identifiers

PMID42681322

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.