ArticleMethods in molecular biology (Clifton, N.J.)2026
Target-Directed miRNA Degradation: Mechanisms and Significance.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are small noncoding RNAs that regulate gene expression within cells through the translational repression or degradation of targeted mRNA. miRNAs undergo a multiphase synthesis that includes conformational changes mediated by Drosha, Dicer, and Argonaute to integrate mature miRNA into the RNA-induced silencing complex to target messenger (m)RNA. miRNAs have been characterized through their transcription and biogenesis; however, the mechanism regarding miRNA turnover is less comprehensible because of the stability of each miRNA. Target-directed miRNA degradation (TDMD) is dependent on the stability of miRNAs, which modulates the decay rate of miRNAs. This mechanism is initiated through target RNAs' engagement with miRNAs via the 3' end complements, which induces Argonaute rearrangement. These rearrangements of Argonaute can be induced through tailing and trimming, with one of the central initiators being the ZSWIM8 E3 ubiquitin ligase. Tailing and trimming are often associated with TDMD, and the mechanistic role is context-dependent. This mechanism provides a regulation process in which mRNA is actively repressed and silenced by the miRNA. The significance of TDMD lies in its role in post-transcriptional regulation of miRNA expression, its implications for therapeutic treatments, and its association with various diseases.
Indexed as
Identifiers
42681318What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.