Evidence map›Paper›PMID 42681200›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Detection of MicroRNAs Released from Argonautes.

Ji Won Lee, Chang Hoon Shin, J Grayson Evans, Erick C Won, Je-Hyun Yoon, Kyung-Won Min

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ji Won LeeDepartment of Biological Sciences, College of Natural Sciences, Kangwon National University, Gangneung Campus, Gangneung, South Korea.
Chang Hoon ShinDepartment of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK, USA.
J Grayson EvansDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Erick C WonDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Je-Hyun YoonDepartment of Oncology Science, College of Medicine, University of Oklahoma, Oklahoma City, OK, USA. jehyun-yoon@ouhsc.edu.
Kyung-Won MinDepartment of Biological Sciences, College of Natural Sciences, Kangwon National University, Gangneung Campus, Gangneung, South Korea. minkw@kangwon.ac.kr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Argonaute (AGO) family of proteins is fundamental to microRNA (miRNA)-mediated gene silencing, serving as the central component of the RNA-induced silencing complex (RISC) by forming direct and stable binding with mature miRNAs. While miRNA-AGO interactions are essential for controlling gene expression and closely linked to human disease, AGO-free mature miRNAs also contribute to fine-tuning gene expression regulation through direct interaction with RNA-binding proteins (RBPs). This chapter presents a detailed biochemical methodology to quantify single-stranded mature miRNAs dissociated from AGO2, providing an approach to studying miRNAs release mechanisms.

Indexed as

Argonaute ProteinsMicroRNAsHumansRNA-Binding ProteinsRNA-Induced Silencing ComplexArgonaute ProteinsMicroRNAsRNA-Binding ProteinsRNA-Induced Silencing ComplexArgonautesmicroRNAsmicroRNAs releaseqPCRRibonucleoprotein complexes (RNPs)RNA-binding proteins (RBPs)

Identifiers

PMID42681200

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.