Evidence map›Paper›PMID 42681163›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Targeting Collagens and LOX Through Plant-Derived MicroRNAs (XenomiRs).

Paraskevi Ioannou, Sylvia Mangani, Elias Katsoulieris, Katerina-Marina Pilala, Konstantinos Soureas, Andreas Scorilas, Irit Sagi, Margaritis Avgeris, Nikolaos A Afratis

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Paraskevi IoannouLaboratory of Biotechnology and Molecular Analysis, Department of Agricultural Development, Agri-food & Management of Natural Resources, National and Kapodistrian University of Athens, Evripos Campus, Psachna, Evia, Greece.
Sylvia ManganiLaboratory of Biotechnology and Molecular Analysis, Department of Agricultural Development, Agri-food & Management of Natural Resources, National and Kapodistrian University of Athens, Evripos Campus, Psachna, Evia, Greece.
Elias KatsoulierisLaboratory of Biotechnology and Molecular Analysis, Department of Agricultural Development, Agri-food & Management of Natural Resources, National and Kapodistrian University of Athens, Evripos Campus, Psachna, Evia, Greece.
Katerina-Marina PilalaDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos SoureasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Andreas ScorilasDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Irit SagiDepartment of Immunology and Regenerative Biology, The Weizmann Institute of Science, Rehovot, Israel.
Margaritis AvgerisDepartment of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, Greece.
Nikolaos A AfratisLaboratory of Biotechnology and Molecular Analysis, Department of Agricultural Development, Agri-food & Management of Natural Resources, National and Kapodistrian University of Athens, Evripos Campus, Psachna, Evia, Greece. nafratis@agro.uoa.gr.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagens and Lysyl Oxidases shape the extracellular matrix, with their dysregulation promoting matrix stiffness and pathological conditions. Plant-derived microRNAs (xenomiRs) can act across species, potentially modulating human physiology. Here, we present a robust protocol for isolating and sequencing xenomiRs from plants of the Evia region of Greece and predicting their human targets, highlighting their potential to regulate collagens and lysyl oxidases and providing a framework for cross-kingdom therapeutic approaches.

Indexed as

CollagenMicroRNAsPlantsProtein-Lysine 6-OxidaseRNA, PlantHumansCollagenMicroRNAsProtein-Lysine 6-OxidaseRNA, PlantCollagensCustom Target PredictionIn Silico miRNA Sequence AnalysisLOXsPlant miRNAsRNA extractionSmall RNA SequencingXenomiRs

Identifiers

PMID42681163

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.