Evidence map›Paper›PMID 42681152›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Hypoxia in Cellular Behavior, Collagen Biosynthesis, and Extracellular Matrix Production.

Linda Birgisdóttir, Sotiria Tsiflidou, Emma Karjalainen, Johanna Myllyharju, Joni M Mäki, Antti M Salo, Anu Laitala

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda BirgisdóttirFaculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland.
Sotiria Tsiflidou
Emma Karjalainen
Johanna Myllyharju
Joni M Mäki
Antti M Salo
Anu LaitalaFaculty of Biochemistry and Molecular Medicine, Oulu Center for Cell-Matrix Research, University of Oulu, Oulu, Finland. anu.laitala@oulu.fi.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Collagens make up a major part of extracellular matrix (ECM) proteins, and their mechanical and chemical properties are regulated by collagen-modifying enzymes. The expression and activity of these enzymes are influenced by hypoxia through hypoxia-inducible factor (HIF), which plays a role in both physiological and pathological conditions. This chapter presents protocols for studying the effects of hypoxia on ECM, cell behavior, and collagen production, utilizing specialized hypoxia workstations for controlled cell culture conditions.

Indexed as

CollagenExtracellular MatrixAnimalsCell Culture TechniquesCell HypoxiaHumansCollagenCellular behaviorCollagen extractionCollagen-modifying enzymesExtracellular matrixHypoxia

Identifiers

PMID42681152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.