Evidence map›Paper›PMID 42681100›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Fmoc-Based Assembly of PNA Oligomers: Manual and Microwave-Assisted Automated Synthesis.

Henrik Franzyk, Anna Mette Hansen, Ashif Yasin Shaikh

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Henrik FranzykFaculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Anna Mette HansenFaculty of Health and Medical Sciences, Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark.
Ashif Yasin ShaikhDepartment of Chemical Sciences, University of Parma, Parma, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PNA-peptide conjugates are explored as potential antisense drugs and as probes in molecular biology, which demands rapid and efficient synthesis protocols that enable isolation of amounts suitable for establishing structure-activity relationships and for in vivo studies in animal disease models. Here, Fmoc/Boc-protected PNA monomers are utilized in the assembly of oligomers via optimized protocols involving either manual synthesis at room temperature or automated microwave-assisted coupling of monomers using a peptide synthesizer.

Indexed as

FluorenesMicrowavesPeptide Nucleic AcidsSolid-Phase Synthesis TechniquesFluorenesPeptide Nucleic AcidsAntisense oligomersCoupling conditionsFmoc deprotectionMicrowave heatingPeptide nucleic acidSolid-phase synthesis

Identifiers

PMID42681100

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.