Evidence map›Paper›PMID 42681094›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2026

Monomer Synthesis and On-Resin Chemical Functionalization of Gamma Peptide Nucleic Acid.

Savani W Thrikawala, Babita Aryal, Danith H Ly

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Savani W ThrikawalaDepartment of Chemistry and Institute for Biomolecular Design and Discovery (IBD), Carnegie Mellon University, Pittsburgh, PA, USA.
Babita AryalDepartment of Chemistry and Institute for Biomolecular Design and Discovery (IBD), Carnegie Mellon University, Pittsburgh, PA, USA.
Danith H LyDepartment of Chemistry and Institute for Biomolecular Design and Discovery (IBD), Carnegie Mellon University, Pittsburgh, PA, USA. dly@andrew.cmu.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This chapter presents methods for synthesizing gamma peptide nucleic acid (γPNA) monomers and oligomers with lysine side chains bearing orthogonal Alloc-protecting groups. These protecting groups can be selectively removed under mild conditions on resin, enabling site-specific functionalization with diverse chemical groups. This approach streamlines synthesis, preserves the structural integrity of γPNA, and broadens its potential applications in biomedical research and development.

Indexed as

Peptide Nucleic AcidsPeptide Nucleic AcidsGamma peptide nucleic acid (γPNA)Gamma PNA monomers/oligomersImproved/streamlined synthesis

Identifiers

PMID42681094

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.