ArticleMethods in molecular biology (Clifton, N.J.)2026
Isolation of Centrosomal Fractions for Proteomic Studies in Lymphocytes.
Article in Methods in molecular biology (Clifton, N.J.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Centrosomes are essential microtubule-organizing centers that coordinate spatial cues for cellular polarization and organelle trafficking. In T lymphocytes, centrosomes translocate toward the immunological synapse to orchestrate polarized secretion and sustain signaling with the antigen-presenting cell. Understanding the dynamic composition of the centrosome during lymphocyte activation is crucial for uncovering the molecular mechanisms behind immune responses. Here, we describe a detailed protocol to isolate centrosome-enriched fractions from human T lymphoblasts under near-physiological conditions, optimized for downstream applications such as proteomic or structural analyses.
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