ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Prognostic value of the identified genus of anaerobic bacteria in bloodstream infection beyond host-related risk factors: a five-year retrospective cohort study.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnaerobic bacteraemia is an uncommon but clinically significant bloodstream infection associated with substantial mortality. The respective roles of pathogen-specific and host-related factors in determining outcomes are not fully elucidated.
aimTo identify predictors of mortality in anaerobic bacteraemia and to evaluate whether genus-based microbiological classification offers prognostic value beyond established clinical risk factors.
methodsA retrospective cohort study was performed involving patients with anaerobic bacteraemia (n = 96) treated at a tertiary-care centre in Hungary from January 2021 to December 2025. Survival was analysed using Kaplan-Meier estimates and Cox proportional hazards regression. The incremental prognostic value of anaerobic genus was assessed using nested multivariable models, with Firth-penalised logistic regression applied as a sensitivity analysis.
resultsAmong 96 patients (median age 68 years), the most common isolates were Bacteroides spp. (33%), Clostridium spp. (17%), Actinomyces spp. (16%), and Fusobacterium spp. (9%). Mortality rates were 43.8% at 30 days, and 54.2% at 180 days. Survival varied significantly by genus, with Clostridium spp. bacteraemia exhibiting the highest mortality (75.0%). Independent predictors of 180-day mortality were increasing age (HR 1.03, p = 0.037), acute kidney injury (HR 2.27, p = 0.007), liver cirrhosis (HR 2.83, p = 0.022), hypertension (HR 1.95, p = 0.048), and Clostridium spp. bacteraemia (HR 3.00, p = 0.006). Microbiological classification significantly improved model performance (likelihood-ratio p = 0.016). The final model had an apparent 180-day AUC of 0.81.
conclusionsBacterial genus provides prognostic information beyond host-related risk factors in anaerobic bacteraemia. Clostridium spp. bacteraemia was associated with the highest mortality and independently predicted 180-day mortality.
Indexed as
Identifiers
42680942What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.