ReviewNature reviews. Neurology2026
Effects of obesity on brain health and cognition.
Review in Nature reviews. Neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a global health issue, and cognitive impairment and elevated risk of dementia are emerging as important consequences. Clinical studies have documented that obesity over the life course is associated with cognitive decline, with midlife obesity carrying a particularly high risk. Evidence from both preclinical and clinical studies suggests that obesity has multiple pathophysiological effects on the brain, including hypothalamic dysregulation and disruptions in biological processes that affect the hippocampus and prefrontal cortex, such as metabolic, inflammatory and vascular dysfunction. In this Review, we summarize the global epidemiology of obesity and examine its clinical relevance as a risk factor for cognitive impairment and dementia. We also discuss the peripheral and central mechanisms through which obesity affects brain function and review obesity-related interventions that have been shown to improve cognition. We conclude by identifying crucial gaps in the existing clinical, translational and intervention-focused literature that warrant future investigation.
Identifiers
42680929What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.