ArticleNature neuroscience2026
State-dependent signal flow hierarchy in the human cerebral cortex.
Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Update of
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Understanding how information flows across distributed brain networks is central to linking brain structure, dynamics and function. Here we present a neuroimaging framework that combines integrated effective connectivity (iEC) and unconstrained signal flow mapping for data-driven identification of human cerebral functional hierarchies. Simulations and empirical validation show that iEC recovers connectome directionality and aligns with histologically defined feedforward and feedback pathways. The iEC-derived hierarchy exhibits a monotonically increasing level along the axis where the sensorimotor, association and paralimbic areas are sequentially ordered, consistent with predictions from the structural model of laminar connectivity. This hierarchy is not fixed but flexibly reorganizes across brain states; it becomes flatter during externally oriented processing and steeper during internally focused conditions, reflecting increased engagement of interoceptive regions. Our study indicates that macroscale directed functional connectivity can reveal biologically grounded, state-dependent principles of signal flow in the human brain.
Identifiers
42680907What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.